acetaminophen intoxication

服藥24小時內, 根據Rumack normogram給予治療
服藥超過24小時, 已具肝功能有無異常給予治療

Stage:
1    hours                  nausea, vomiting
2   24~72 hours      elevated LFTs, RUQ pain
3   3~5 days             jaundice, hepatic failure
4     one week          recovery

N-acetylcysteine
PO: 140 mg/kg, than 70 mg/kg, total 18 dose
IV: 150 mg/kg for 15 min, 50 mg/kg for 4 hours, 100 mg/kg for 14 hours  or
      140 mg/kg for loading, than 70 mg/kg every 4 hour, total 13 dose

如acetaminophen 濃度小於10 mg/L, 且AST為正常, 可不需治療